Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. The effectiveness of Propranolol appears to be its principal ant arrhythmic mechanism of action. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. Treatment must always be initiated and individual titration of dosage carried out using the conventional tablets. The combination of Propranolol with thiazide-like diuretics and peripheral vasodilators has been shown to be compatible and generally more effective than Propranolol alone.