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Although some side effects can be serious. Take additional cephalosporin antibiotics as this is likely to result in an overdose. Keflex can be used as first-line therapy for MRSA infections and is the most prescribed oral cephalosporin medicine. This is likely to result in an overdose. Patients and a thorough medical history is recommended prior to prescribing this medication. Additional antibiotics should be avoided entirely while you are taking Cephalexin.